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Symbol
Name
ID

Adam22
a disintegrin and metallopeptidase domain 22
MGI:1340046

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Secondary microcephaly	Spasticity	Cerebral atrophy	Reduced eye contact	Intellectual disability, profound	Loss of ambulation	Epileptic encephalopathy	Seizure	Bilateral tonic-clonic seizure with focal onset	Focal clonic seizure
Disease(s) Associated with ADAM22
developmental and epileptic encephalopathy 61

Mouse Phenotypes		nervous system phenotype	convulsive seizures	abnormal glial cell morphology	abnormal Schwann cell morphology	abnormal neuron morphology	abnormal myelination	demyelination
Availability	Mouse Genotype	nervous system phenotype	convulsive seizures	abnormal glial cell morphology	abnormal Schwann cell morphology	abnormal neuron morphology	abnormal myelination	demyelination
	Adam22^tm1Sag/Adam22^tm1Sag
	Adam22^tm1.1Mejr/Adam22^tm1.1Mejr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)
	Adam22^tm1.1Mejr/Adam22^tm1.1Mejr Tg(Dhh-cre)1Mejr/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23